Constipation isn’t exactly a fun topic of discussion, but if you’ve started semaglutide, chances are you either experienced constipation or heard of someone else who has.
In fact, semaglutide constipation is one of the most common side effects reported by patients who are using this medication.
Understanding what causes constipation when taking semaglutide, and what you can do to ease this side effect, can make a big difference in how you feel day to day.
Read on for more information about the ‘why’ behind semaglutide’s most notorious side effect, and what you can do to get back to being ‘regular’.
Why Does Semaglutide Cause Constipation?
Semaglutide is part of a list of medications called GLP-1 receptor agonists. It’s prescribed to help with blood sugar control in people with type 2 diabetes, and it’s also FDA-approved for weight loss under brand names like Wegovy.
While these medications can be very effective, they may also impact your digestive system in a few ways:
- Slower digestion: One of the ways semaglutide helps manage blood sugar is by slowing down how quickly food moves through your stomach. This “delayed gastric emptying” helps you feel fuller longer, but it also slows down the whole digestive process, which can lead to constipation.
- Appetite suppression: People on semaglutide often eat less. When you consume less food, there’s less material moving through your digestive tract, and that can reduce the frequency of bowel movements.
- Dehydration: A reduced appetite may also mean you’re not drinking enough fluids, which plays a major role in stool softness and regularity.
Is Constipation Dangerous?
Occasional constipation isn’t usually a cause for concern, but it can certainly make you uncomfortable. If left unmanaged, it can lead to:
- Bloating
- Gas
- Abdominal pain
- Hemorrhoids from straining
- Rectal discomfort or anal fissures
And in rare cases, severe constipation can lead to impaction (where stool gets stuck in the colon and can’t pass on its own). So while semaglutide constipation is usually mild to moderate, it’s still important to treat it seriously.
Relief Tips for Semaglutide Constipation
If you’re experiencing constipation after starting semaglutide, don’t worry, there are several gentle, effective ways to get things moving again.
1. Hydrate More Than You Think You Need
You’ve heard it before, but it’s worth repeating: water is your best friend. Aim for at least 8–10 cups per day, and more if you’re active or live in a hot climate. Water helps keep stool soft and easier to pass.
Pro tip: If plain water isn’t cutting it, try adding electrolyte packets or slices of fruit for flavor and hydration support.
2. Add More Fiber, Gradually
Fiber adds bulk to your stool and helps it move through your system more efficiently. Good sources include:
- Vegetables (especially leafy greens, broccoli, and carrots)
- Fruits (especially berries, pears, and apples with the skin)
- Whole grains (like oats, quinoa, and brown rice)
- Legumes (beans, lentils, chickpeas)
Important: Increase fiber gradually and pair it with extra water to avoid making constipation worse.
3. Stay Active
Movement helps digestion! Regular light exercise like walking, stretching, or yoga can stimulate the muscles in your digestive tract. Even 15–30 minutes a day can make a noticeable difference.
4. Establish a Bathroom Routine
It sounds silly, but your body loves routine. Try setting aside 10–15 minutes at the same time each day (preferably after meals) to sit on the toilet, even if you don’t feel the urge. This helps “train” your body to become more regular.
Also: don’t ignore the urge to go. Holding it in can worsen constipation over time.
5. Consider a Fiber Supplement or Stool Softener
If lifestyle changes aren’t enough, talk to your doctor about using:
- Psyllium husk (like Metamucil)
- Stool softeners (like docusate sodium)
- Osmotic laxatives (like polyethylene glycol/ MiraLAX)
These are generally safe options for semaglutide users, but it’s always best to consult your provider before starting any new supplement or over-the-counter treatment.
When to Call Your Doctor
If your constipation lasts more than a few days or becomes painful, it’s time to check in. You should also call your provider if you notice:
- Blood in your stool
- Severe bloating or cramping
- Vomiting along with constipation
- No bowel movement for more than 3 days despite trying the above strategies
At Family Tree Primary Care, we’re always just a message away, whether you’re dealing with constipation or simply adjusting to life on semaglutide.
You’re Not Alone
Constipation can be frustrating, uncomfortable, and even a bit embarrassing when you have to talk about it. However, it’s more common than you might think among people taking semaglutide.
The good news is that with a few adjustments and a little patience, most people are able to manage it with some tweaks.
If you’re struggling with semaglutide side effects, make sure you reach out to your provider at Family Tree Primary Care. We are here to support you with personalized guidance and real solutions that work for your body.
Give us a call today, we are happy to help.
